### JEAN CLAUDE PEREZ, GABRIELLE LOSA AND ANDRAS J PELLIONISZ GIANTS IN FRACTAL GENOMICS: SCIENCE BEYOND BOUNDARIES, WITH M.V.RAMANUJAM.

# Jean-claude Perez

*"DRAGON fractal paper folding curve"*fine-tuned around the

*"Golden ratio"*. Particularly, this main paper entitled

*shows that the*

**"Codon populations in single-stranded whole human genome DNA are fractal and fine-tuned by the Golden Ratio 1.618."***Universal Genetic Code Table*not only maps codons to amino acids, but serves as a global checksum matrix at the whole genome macro-structural scale.

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A complete summary of J.C Perez's research was published in Pellionisz A., Graham R., Pellionisz P., Perez J.:

^{[14]}In: Manto M., Gruol D., Schmahmann J., Koibuchi N., Rossi F. (Ed.) Handbook of the Cerebellum and Cerebellar Disorders:^{[15]}Details in this chapter^{[16]}and full paper available in this book^{[17]}
In October 2013, Jean-Claude Perez published a peer reviewed major article in [APPLIED MATHEMATICS]

^{[18]}entitled**"The 3 genomic numbers discovery"**. This article shows - for the first time - that complete human genome single stranded DNA constitutes a WHOLE.**In July 2015 Jean-Claude Perez published his main peer-review article ... Deciphering Hidden DNA Meta-Codes -The Great Unification & Master Code of Biology**

^{[19]}**In summer 2017 Jean-Claude Perez published a set of major peer reviewed articles in various interdisciplinary fields like:**mtDNA genome, whole human genome metastructures, CANCER mutations, SNPs (Single-Nucleotide Polymorphism), HIV virus genomes, I.Q and BRAIN numerical waveforms, or... MENDELEEV periodic table and quantum physics numerical structures...

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Jean-Claude Perez
Individual researcher 7 Avenue de Terre-rouge 33127, Martignas, France Phone: (33) 0781181112 Email: ^{[21]} |

**An overview of INTERDISCIPLINARY RESEARCH WEB LINKS is available in the page**

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It may be important to note that Jean-claude Perez does not consider himself a creationist: his main question is:

"How is the mystery of Life emerging? By Self-organization or God? Yet certainly not by Random Chance or Hazard! Another pending second question is related to the central role played by INTEGER NUMBERS, the GOLDEN RATIO, and MATHEMATICS in hidden rules of LIFE...""My main research is "SELF-ORGANIZATION"^{[23]}: and then, could self-organization explain the genesis of LIFE? Presently, after nearly 30 years of research around this central question, I have no consistent response..."^{[24]}^{[25]}

## Contents

[hide]- 1 1991: The
**"DNA SUPRACODE"**: Relative proportions of TCAG nucleotides within DNA Genetic coding obey the same proportions as Fibonacci's numbers - 2 1994:
**"THE FIRST MUSIC OF GENES"**reveals in AUDIO MEDIA the super structure of GENETIC-coding DNA discovered in "DNA SUPRACODE" - 3 1994:
**"NUMBERS IN MATTER"**- Optimizing High Temperature Superconductors by Golden Ratio - 4 1997:
**"NUMBERS in ATOMS"**- a basic NUMERICAL FORMULA PREDICTS the whole STRUCTURE of MENDELEEV's PERIODIC TABLE - 5
**"NUMBERS IN DNA"**: Why are FRACTALS and INTEGER NUMBERS structuring WHOLE HUMAN GENOME DNA? - 6 2009: The book
**"CODEX BIOGENESIS: les 13 codes de l'ADN"** - 7 ANALYSING CODON FREQUENCIES IN WHOLE HUMAN GENOME: towards long-range global scale FUNCTION of "noncoding JUNK-DNA"
- 8 Binary and Undulatory CODES emerging from DNA: scale invariance in information make a level LOGICAL FRACTAL GENOME
- 9
**Is There "an EQUATION of LIFE"?** - 10 March 2011: A synthetic conference about 20 years of research on "NUMBERS IN DNA"
- 11 External links
- 12 References
- 13 Bibliography
- 14 Other collections
- 15 Quoted references from others books
- 16 Awards
- 17 External links

##
1991: The **"DNA SUPRACODE"**: Relative proportions of TCAG nucleotides within DNA Genetic coding obey the same proportions as Fibonacci's numbers

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Examples involving evolution and pathogen analysis include genes or small gene-rich genomes, especially the HIV genome. This book explores a numerical property called the “DNA Supracode” consisting of exhaustive combinatorial research of “resonances” within gene-coding DNA sequences: a resonance is a harmonious proportion of exact Fibonacci/Lucas nucleotide numbers.

*For example: 144 contiguous TCAG nucleotides have exactly 55 T nucleotides and 89 A or C or G nucleotides.*Then a resonance exists with an the Golden ratio as defined in the Methods section: 55, 89 and 144 are consecutive Fibonacci numbers following the Golden Ratio. Gene-rich genomes like HIV have thousands of “resonances”, where the longer ones overlap 2/3rds of the whole genome length.^{[27]}##
1994: **"THE FIRST MUSIC OF GENES"** reveals in AUDIO MEDIA the super structure of GENETIC-coding DNA discovered in "DNA SUPRACODE"

Observing this image of the dynamics of Fibonacci's DNA supracode resonances, Jean-claude Perez had the immediate intuition of showing this pattern in a different media: MUSIC... More in the Full CD audio of "THE FIRST MUSIC OF GENES"

and "Numbers in Matter"^{[28]}^{[29]}

##
1994: **"NUMBERS IN MATTER"** - Optimizing High Temperature Superconductors by Golden Ratio

The question of how superconductivity emerges spontaneously from high-temperature superconductors is one of the major unsolved problems of theoretical Physics. In 2010, the famous discovery by Antonio Bianconi et al. shows evidence of fractal structure in high temperature superconductors.

^{[30]}meanwhile, 16 years ago, in 1994, Jean-claude Perez published an international patent proposing to optimize high temperature superconductors using a specific region of the FRACTALS spectrum: the GOLDEN RATIO.^{[31]}
In fact, J.C. Perez's main investigation is about this mysterious trilogy: -Fractal worlds. -Golden ratio. -and high level structures emerging from matter (high temperature superconductors) or life (DNA). More details in the article "Golden Ratio and Fractals".

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1997: **"NUMBERS in ATOMS"** - a basic NUMERICAL FORMULA PREDICTS the whole STRUCTURE of MENDELEEV's PERIODIC TABLE

**The discovery of a Mathematical formula for the periodic law:**

Discovered in 1997,

^{[33]}Jean-claude Perez published in 2009 in the book "CODEX BIOGENESIS",^{[34]}a very simple numerical formula computing the number of elements within every period then, finally, within the whole structure: In this elementary predictive formula,**"p"**is the period number,**"c(p)"**is the number of Elements within the period layer and**"Int(x)"**is the integer whole value of real number x. More details in this image^{[35]}and this article.^{[36]}##
**"NUMBERS IN DNA"**: Why are FRACTALS and INTEGER NUMBERS structuring WHOLE HUMAN GENOME DNA?

In October 2009, there were two major breakthroughs along the way to prove the FRACTAL nature of the whole HUMAN GENOME DNA:

- The PHYSICAL FRACTAL GENOME: the publication in SCIENCE by Erez Lieberman-Aiden entitled
*" Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome "*demonstrates that the three dimensional folding of the 2 meter long DNA molecule within each cell is FRACTAL. - The LOGICAL FRACTAL GENOME: the book
*CODEX BIOGENESIS: les 13 codes de l'ADN (the 13 codes of DNA)*was published by Jean-claude Perez. This book demonstrates, principally by analyzing codon frequencies within the whole human genome, that the DNA sequence of the simple stranded DNA double helix is organized on a FRACTAL law.

**Interacting independent proofs include particularly:**

**NUMBER "2"**: mirror symmetry of codons within simple stranded DNA,^{[37]}**NUMBERS "2" and "3"**: "Peace symbol" geometrical proportions between codon clusters,^{[38]}. Then, linking the Genome with Music, a wave ratio proportion of "2" appears = one octave between the 32 more frequent codon populations and the 32 remaining other codon populations,**NUMBERS "12" and "13"**: When numbers 12 and 13 emerge from relative proportions of TTT+AAA codons and the whole genome single-stranded codon populations.^{[39]}- the modeling of codon populations is controlled by the
**DRAGON's fractal paper folding curve**applied to the universal genetic code map playing the role of a

**"Checksum-like MATRIX"**controlling codon populations exactly,

**Numerical fine-tuned BALANCE**: Analysing human genome DNA sequences at the atomic mass level, the proof of the emergence of binary and undulating codes which control DNA fractally in a scale invariant way.**GOLDEN RATIO**: evidence of the golden ratio proportion controlling globally the whole human genome both in DNA coding and junk-DNA sequences.

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2009: The book **"CODEX BIOGENESIS: les 13 codes de l'ADN"**

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Visit the content of the book on AMAZON here.

^{[43]}## ANALYSING CODON FREQUENCIES IN WHOLE HUMAN GENOME: towards long-range global scale FUNCTION of "noncoding JUNK-DNA"

In chapter 16 of CODEX BIOGENESIS (published in october 2009)

^{[44]}, I prove that the approximately 1 billion codons of the human genome obey an organization where the universal 64 codons make a universal genetic code map… which involves another neighbouring fractal, The DRAGON curve.^{[45]}^{[46]}^{[47]}
More details on how the DRAGON’s curve structures the human genome codon populations vs the UNIVERSAL GENETIC CODE map from the book CODEX BIOGENESIS.

^{[48]}**When the "Peace Symbol" image emerges from proportions between codon populations within the whole HUMAN GENOME DNA**

**Chapter 16: “MATRIX”: the folding codes of the « human genome dragon - SUMMARY -**

We offer here an amazing law which comes down to:

*« The respective POPULATIONS of each of 64 codons constituting the whole human genome are CONTROLLED by LOCATIONS of these same codons inside the ” Universal Genetic Code ” map ».*
Effectively; by analysing the distribution of frequencies in an exhaustive way for each of 64 codons of the genetic code inside the single strand of DNA which results from the end to end concatenation of our 24 chromosomes, it appears, strangely enough, that the populations of these hundreds of million of codons are controlled by their respective and definite locations within the universal genetic code table. The universal genetic code table would constitute therefore a kind of “structure”, or “frame” of the “MATRIX” among which the respective LOCATIONS and POSITIONS of each one of 64 codons WOULD D_E_T_E_R_M_I_N_E the exact POPULATIONS of these same codons! The unforeseen means which allowed us to throw into relief this relationship is a scientific result resembling more the domain of « strangeness and mathematical games » rather than that of “hard” renowned sciences such as Genetics: the “DRAGON curve”. The 6 successive embedded foldings, according to successive dichotomies of the dragon’s curve applied to the respective populations – on the scale of whole human genome – of each of the 64 codons ordered according to the genetic code map go on then to reveal the omnipresence of 2 kinds of dual attractors with remarkable values. We conclude from this therefore that each of positions of the 64 codons within the universal genetic code table WOULD DETERMINE respective population values of these same codons within the whole human genome.

## Binary and Undulatory CODES emerging from DNA: scale invariance in information make a level LOGICAL FRACTAL GENOME

##
**Is There "an EQUATION of LIFE"?**

Scale Invariance, self similarity, and binary / undulatory language emerges from the whole human genome analysed from a DNA sequence at the atomic mass level… This shows the route of a

**"great unification"**of all Biological Information: DNA, RNA, amino acid sequences, proteins, genes and genomes...^{[49]}. More in the CODEX BIOGENESIS book.^{[50]}^{[51]}^{[52]}## March 2011: A synthetic conference about 20 years of research on "NUMBERS IN DNA"

**A speech in WORLD VACCINES CONGRESS BEIJING CHINA March 2011...**

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ReplyDelete

ReplyDelete==> ==> In summer 2017 and 2018, Jean-Claude Perez published about 20 major peer reviewed articles in various interdisciplinary fields like: A major paper entitled "A proof of the unity, integrity and autopoietic autonomy of the whole human genome",

==> ==> mtDNA genome,

==> ==> Human Genome Optimal Cancers LOH Mutations STRATEGY,

==> ==> Fractal Human Chromosome4 standing waves,

==> ==> CANCER mutations global strategies,

==> ==> SNPs Functional strtegy (Single-Nucleotide Polymorphism),

==> ==> HIV virus genomes,

==> ==> I.Q and BRAIN numerical waveforms,

==> ==> ALZHEIMER Disease

==> ==> or... MENDELEEV periodic table predictive formula

==> ==> and quantum computing in CANCER,

==> ==> and more... [20]